The Trio Zone.
It’s the Heart
of Protection.

Now FDA-approved to block infections that may cause Lyme disease*

*as a direct result of killing Ixodes scapularis.

All this coverage in just one monthly chewable

Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable—for protection against:

  • Heartworm disease
  • Ticks* & fleas
  • Roundworms & hookworms
  • Infections that may cause Lyme disease by killing deer ticks

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*Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, Rhipicephalus sanguineus.
Toxocara canis, Toxascaris leonina, Ancylostoma caninum and Uncinaria stenocephala.

Simparica Trio is designed for defense

Just one Simparica Trio chewable does the job of two or three parasiticides in a single chewable—the way pet owners prefer to give preventatives to their dogs.3

safe for dogs

Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more

Highly palatable1
liver-flavored chewable

Can be given with or without food. Consumed by free choice or with food 91.9% of the time

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Compare the labels of other products with Simparica Trio

* by killing deer ticks

Heartgard® and NexGard® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. 8,9
Credelio®, Interceptor®, and Trifexis® are registered trademarks of Elanco or its affiliates. 10,11,12
Bravecto® is a registered trademark of Intervet Inc. d/b/a Merck Animal Health.13

In clinical studies, Simparica Trio was 100% effective against heartworm disease

Heartworm disease is a year-round threat that has been diagnosed in all 50 states. Clinics reported a 21% increase in heartworm positive cases in a 3 year period.7

Infection is widespread across the US

as shown by sales of 1 heartworm treatment6

*Map based on 2018 Diroban® (melarsomine dihydrochloride) sales.

Just one Simparica Trio chewable delivered fully effective heartworm disease protection

In two well-controlled laboratory studies, a single oral dose of Simparica Trio was 100% effective in preventing the development of heartworm disease in dogs inoculated with infective larvae 30 days before treatment.

Simparica Trio was designed for balancing optimal effectiveness with safety to prevent heartworm disease

Keep dogs protected from ticks and fleas

It only takes one infected tick to spread disease. Ticks are responsible for transmitting at least 15 different serious diseases to dogs, including Lyme disease, and are active throughout the year.8

Flea infestations may take several months to resolve, are frustrating, and can be costly. Flea allergy dermatitis can result in symptoms for dogs.*

*Symptoms can include erythema, papules, scaling, alopecia, dermatitis/pyodermatitis, and pruritus.

Your recommendation matters

Simparica Trio is proven to kill 5 species of ticks

FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks

Demonstrated ≥98.9% effectiveness against existing tick infestations in 48 hours†‡

Effective against ticks that may carry debilitating diseases like ehrlichiosis, anaplasmosis, and rickettsiosis2

Simparica Trio protects against fleas

Starts killing fleas within 4 hours

Achieved 100% efficacy 8 hours after treatment in a study

Substantially improved the clinical signs of flea allergy dermatitis

†In well-controlled laboratory studies.
‡Against Amblyomma americanum, Simparica Trio was 99.4% effective 72 hours after treatment of existing infestations.

Treatment and control of roundworms and hookworms

Treat and control intestinal parasites to protect dogs. Contaminated environments put pets and people at risk of zoonosis.

Just one monthly Simparica Trio chewable offers protection from roundworms and hookworms

Pyrantel protects against intestinal parasites

In clinical studies, Simparica Trio was 99.2% effective for adult roundworm and reduction in fecal egg count5†

Demonstrated >94% efficacy for hookworm, in studies4††

†Also effective against immature adult stage of T. canis.6
††For L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala.

Simparica Trio Rewards

For Your Practice
My Zoetis Rewards

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for your practice.

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For Pet Owners
Zoetis Petcare Rewards

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Clinic & Staff Resources

Benefits of protection

View the benefits of Simparica Trio in this quick video.

Implementation video

See 3 simple steps to making Simparica Trio an easy choise for your clinic.

Pet Owner Resources

Waiting room video

Share the benefits of Simparica Trio with your clients.

In-clinic poster

Use this in your waiting room or exam room to inform clients.

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Product Details

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The Simparica Trio Guarantee

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Clinical Studies & Resources

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IMPORTANT SAFETY INFORMATION:  See Full Prescribing Information. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.