All this coverage in just one monthly chewable
Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable—for protection against:
Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable—for protection against:
Heartworm disease- Ticks* & fleas
- Roundworms & hookworms†
- Infections that may cause Lyme disease by killing deer ticks
*Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, Rhipicephalus sanguineus.
†Toxocara canis, Toxascaris leonina, Ancylostoma caninum and Uncinaria stenocephala.
Simparica Trio is designed for defense
Just one Simparica Trio does the job of two or three parasiticides in a single chewable—the way pet owners prefer to give preventatives to their dogs.1
Just one Simparica Trio does the job of two or three parasiticides in a single chewable—the way pet owners prefer to give preventatives to their dogs.1
Demonstrated safe for dogs
Approved for puppies as young as 8 weeks, weighing 2.8 lbs or more
Highly palatable2 liver-flavored chewable
Can be given with or without food. Consumed by free choice or with food 91.9% of the time
Can be given with or without food. Consumed by free choice or with food 91.9% of the time
See the Simparica Trio difference
Compare the labels of other products with Simparica Trio
*Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, Rhipicephalus sanguineus.
†Ixodes scapularis, Dermacentor variabilis Rhipicephalus sanguineus, and Haemaphysalis longicornis for 12 weeks. Bravecto is not effective againt Amblyomma americanum beyond 8 weeks after dosing.
‡Heartworm disease prevention reached 100% efficacy in clinical studies.
§For heartworm disease prevention, give once monthly for at least 6 months after exposure to mosquitoes.3
||Simparica Trio starts killing deer ticks within 8 hours and starts killing fleas within 4 hours.
¶For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina).
#For the treatment of hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections.
**ProHeart 12 larval and adult stages of Ancylostoma caninum and Uncinaria stenocephala.
††As a direct result of killing deer ticks.
NexGard and Heartgard are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. Bravecto is a registered trademark of Intervet Inc. d/b/a Merck Animal Health. Credelio and Interceptor are registered trademarks of Elanco or its affiliates.
In studies, Simparica Trio was 100% effective against heartworm disease
In studies, Simparica Trio was 100% effective against heartworm disease
Heartworm disease is a year-round threat that has been diagnosed in all 50 states. Clinics reported a 21% increase in heartworm positive cases in a 3 year period.8
Heartworm disease is a year-round threat that has been diagnosed in all 50 states. Clinics reported a 21% increase in heartworm positive cases in a 3 year period.8
Infection is widespread across the US
Infection is widespread across the US
as shown by sales of 1 heartworm treatment9
Map based on 2018 Diroban® (melarsomine dihydrochloride) sales.
as shown by sales of 1 heartworm treatment9
Map based on 2018 Diroban® (melarsomine dihydrochloride) sales.
Just one Simparica Trio chewable delivered fully effective heartworm disease protection
Just one Simparica Trio chewable delivered fully effective heartworm disease protection
Simparica Trio was designed to balance optimal effectiveness with safety to prevent heartworm disease
Keep dogs protected from ticks and fleas
It only takes one infected tick to spread disease. Ticks are responsible for transmitting at least 15 different serious diseases to dogs, including Lyme disease, and are active throughout the year.10
Flea infestations may take several months to resolve, are frustrating, and can be costly. Flea allergy dermatitis can result in symptoms for dogs.*
It only takes one infected tick to spread disease. Ticks are responsible for transmitting at least 15 different serious diseases to dogs, including Lyme disease, and are active throughout the year.10
Flea infestations may take several months to resolve, are frustrating, and can be costly. Flea allergy dermatitis can result in symptoms for dogs.*
*Symptoms can include erythema, papules, scaling, alopecia, dermatitis/pyodermatitis, and pruritus.
Your recommendation matters
Simparica Trio is proven to kill 5 species of ticks
- FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks
- Demonstrated ≥98.9% effectiveness against existing tick infestations in 48 hours†‡
- Effective against ticks that may carry debilitating diseases like ehrlichiosis, anaplasmosis, and rickettsiosis11
Simparica Trio protects against fleas
Simparica Trio protects against fleas
- Starts killing fleas within 4 hours
- Achieved 100% efficacy 8 hours after treatment in a study
- Substantially improved the clinical signs of flea allergy dermatitis
†In well-controlled laboratory studies.
‡Against Amblyomma americanum, Simparica Trio was 99.4% effective 72 hours after treatment of existing infestations.
Treatment and control of roundworms and hookworms
Treatment and control of roundworms and hookworms
Treat and control intestinal parasites to protect dogs. Contaminated environments put pets and people at risk.
Just one Simparica Trio chewable offers protection from roundworms and hookworms
Just one Simparica Trio chewable offers protection from roundworms and hookworms
- Pyrantel protects against intestinal parasites
- In clinical studies, Simparica Trio was 99.2% effective for adult roundworm and reduction in fecal egg count12*
- Demonstrated >94% efficacy for hookworm, in studies13†
*Also effective against immature adult stage of T. canis.9
†For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections.
Simparica Trio rewards
FOR YOUR PRACTICE
My Zoetis Rewards
Sign up for savings when you purchase Simparica Trio for your practice.
FOR PET OWNERS
Zoetis Petcare Rewards
Help dog owners save by earning rewards when they purchase Simparica Trio.
Clinic & staff resources
Benefits of protection
View the benefits of Simparica Trio in this quick video.
Implementation video
See 3 simple steps to making Simparica Trio an easy choice for your clinic.
Pet owner resources
Waiting room video
Share the benefits of Simparica Trio with your clients.
In-clinic flyer
Use this in your waiting room or exam room to inform clients.
Learn more about Simparica Trio
Product Details
The Simparica Trio Guarantee
References
- Foster Rosenblatt US Quantitative Research Findings Final Report. Data on file. Zoetis Inc.
- Study A161C-US-15-634. Data on file. Zoetis Inc.
- Bravecto® [package insert], Summit, NJ: Merck & Co; 2023.
- Credelio® [package insert], Greenfield, IN: Elanco; 2017.
- Interceptor® Plus [package insert]. Greenfield, IN: Elanco; 2020.
- Heartgard® Plus [package insert], Duluth, GA: Boehringer Ingelheim; 2019.
- NexGard® [package insert], Duluth, GA: Boehringer Ingelheim; 2019.
- Drake J, Wiseman S. Increasing incidence of Dirofilaria immitis in dogs in USA with focus on the southeast region 2013–2016. Parasit Vectors. 2018;11(1):39.
- Study A166-US-17-821. Data on file. Zoetis Inc.
- Blagburn BL, Dryden MW. Biology, treatment, and control of tick infestations. Vet Clin North Am Small Anim Pract. 2009;39(6):1173-2000.
- Companion Animal Parasite Council. Ticks. April 12, 2017. https://capcvet.org/guidelines/ticks. Accessed March 17, 2023.
- Study A161C-US-15-530. Data on file. Zoetis Inc.
- Nemex-2 Suspension Approved Package Insert, Kalamazoo, MI: Zoetis Inc; 2019.
STR-00060R3
IMPORTANT SAFETY INFORMATION:
See Full Prescribing Information. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.